Laser research: Immune response, abstract and studies

The Effect Of Endovascular Laser Therapy And Antioxidants On The Immune Status And Energy Metabolism Of Patients With Treatment-Resistant Forms Of Schizophrenia

Kut'ko II, Frolov VM, Pustovoi IuG, Pavlenko VV, Rachkauskas GS. Zh Nevropatol Psikhiatr Im S S Korsakova. 1996;96(2):34-8.

The influence of endovascular laser therapy and of antioxidants on clinical immunological indices and energy metabolism was analysed in 148 schizophrenic patients including 86 patients with shift-like progredient (first group) and 62 patients with continuous-progredient (second group) forms of the disease. Positive trends in psychosis course were observed in 57% of cases in the first group and in 41.9% of patients of the second group. Pronounced improvement of the immunological indices was observed in patients with positive clinical dynamics: decreased peripheral blood immunocytes sensitization to the brain, hepatic, thymus tissue antigens as well as ATP elevation which was evidence of the improvement of energy metabolism.

Immunomodulatory Effect Of Laser On Whole Body Exposure

Ganju L, Salhan A, Karan D, Chanda S, Srivastava KK.
Indian J Exp Biol. 1999 May;37(5):444-9.

Defence Institute of Physiology & Allied Sciences, Timarpur, Delhi, India. All biomedical laser applications are based on the interaction of laser light with biological system. During the past decade considerable evidence has accumulated demonstrating that non-thermal exposure to laser can elicit cellular changes in the immune system. In the present study, we have analyzed the effect of laser on immune response in rats. A group of rats were exposed to 0.225 mu j/cm2 for 90 min for 3 days in specially designed fiberglass chambers. The whole body exposure of rats of He-Ne laser modulated both the humoral and cellular responses to tetanus toxoid stimulation.
Plain red light used as a control for red laser light showed an appreciable degree of response as compared to the control groups, but not to the extent of the response to laser. Non-responders turned responders after exposure to laser. There was no response in unimmunized groups when exposed to laser and red light alone.

The early and heightened immune response and proliferation of lymphocytes after exposure to laser is suggestive of a complex interaction at the cellular immune response level.

Low-Level Laser Irradiation Attenuates Production Of Reactive Oxygen Species By Human Neutrophils
Fujimaki Y, Shimoyama T, Liu Q, Umeda T, Nakaji S, Sugawara K.
Department of Hygiene, Hirosaki University School of Medicine, Japan.
J Clin Laser Med Surg. 2003 Jun;21(3):165-70.

OBJECTIVE: The aim of this study was to examine the effects of low-level laser therapy (LLLT) on production of reactive oxygen (ROS) species by human neutrophils. BACKGROUND DATA: LLLT is an effective therapeutic modality for inflammatory conditions. MATERIALS AND METHODS: The laser device used was the infrared diode laser (GaAlAs), 830-nm continuous wave (150 mW/cm(2)). After irradiation, ROS production by neutrophils was measured using luminol-dependent chemiluminescence (LmCL) and expression of CD11b and CD16 on neutrophil surface was measured by flow cytometry.

RESULTS: The LmCL response of neutrophils was reduced by laser irradiation at 60 min prior to the stimulation with opsonized zymosan and calcium ionophore. The attenuating effect of LLLT was larger in neutrophils of smokers than non-smokers, while the amount of produced ROS was larger in neutrophils of smokers. Expression of CD11b and CD16 on neutrophil surface was not affected by LLLT.

CONCLUSION: Attenuation of ROS production by neutrophils may play a role in the effects of LLLT in the treatment of inflammatory tissues. There is a possible usage of LLLT to improve wound healing in smokers.

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