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Photomedicine and Laser Surgery, Volume 27, Number 2, 2009

Case Report

Photodynamic Therapy Can Be Effective as a Treatment for Herpes Simplex Labialis

Juliana Marotti, D.D.S.,1 Ana Cecília Correa Aranha, D.D.S., Ms.C., Ph.D.,2, Carlos De Paula Eduardo, D.D.S., Ms.C., Ph.D.,2 and Martha Simões Ribeiro, Ph.D.3

Abstract

Background Data and Objective: Herpes is a common infectious disease that is caused by human herpesviruses. Several treatments have been proposed, but none of them prevent reactivation of the virus. This article describes the use of photodynamic therapy (PDT) as a treatment for herpes lesions, and reports on four cases.

Materials and Methods: PDT was used as an adjuvant therapy for the treatment of herpes labialis in four patients. A special type of 0.01% (m/V) of methylene blue solution was applied to the vesicular stage of herpesviral disease and the lesions were irradiated with laser energy (wavelength 660 nm, energy density 120 J/cm2, output power of 40 mW, 2 min per point, 4.8 J of energy/point, at four points). After 24 h the patients returned and phototherapy was repeated with the same equipment, this time with 3.8 J/cm2 and 15 mW, for a total dose of 0.6 J. The same procedure was repeated 72 h and 1 wk later.

Materials and Methods: PDT was used as an adjuvant therapy for the treatment of herpes labialis in four patients. A special type of 0.01% (m/V) of methylene blue solution was applied to the vesicular stage of herpesviral disease and the lesions were irradiated with laser energy (wavelength 660 nm, energy density 120 J/cm2, output power of 40 mW, 2 min per point, 4.8 J of energy/point, at four points). After 24 h the patients returned and phototherapy was repeated with the same equipment, this time with 3.8 J/cm2 and 15 mW, for a total dose of 0.6 J. The same procedure was repeated 72 h and 1 wk later.

Conclusion: Treatment of herpes labialis with PDT was effective, had no side effects, and when associated with laser phototherapy, accelerated the healing process.


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